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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 1
2005 2
2006 1
2007 4
2008 5
2009 1
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2011 5
2012 3
2013 3
2014 3
2015 5
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2018 2
2020 2
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2023 1
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37 results

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Page 1
TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling.
Ciesielska A, Matyjek M, Kwiatkowska K. Ciesielska A, et al. Cell Mol Life Sci. 2021 Feb;78(4):1233-1261. doi: 10.1007/s00018-020-03656-y. Epub 2020 Oct 15. Cell Mol Life Sci. 2021. PMID: 33057840 Free PMC article. Review.
Toll-like receptor (TLR) 4 belongs to the TLR family of receptors inducing pro-inflammatory responses to invading pathogens. ...In this review, we focus on the mechanisms of the internalization and intracellular trafficking of TLR4 and CD14, and also of LPS, in immu …
Toll-like receptor (TLR) 4 belongs to the TLR family of receptors inducing pro-inflammatory responses to invading pathogens. ...In th …
CD14, TLR4 and TRAM Show Different Trafficking Dynamics During LPS Stimulation.
Klein DC, Skjesol A, Kers-Rebel ED, Sherstova T, Sporsheim B, Egeberg KW, Stokke BT, Espevik T, Husebye H. Klein DC, et al. Traffic. 2015 Jul;16(7):677-90. doi: 10.1111/tra.12274. Epub 2015 Mar 24. Traffic. 2015. PMID: 25707286 Free article.
We have investigated the dynamics of TLR4 and TRAM during lipopolysaccharide (LPS) stimulation. We found that LPS induced a CD14-dependent immobile fraction of TLR4 in the plasma membrane. Total internal reflection fluorescence microscopy (TIRF) revealed that LPS st …
We have investigated the dynamics of TLR4 and TRAM during lipopolysaccharide (LPS) stimulation. We found that LPS induced a CD14 …
Development of Exhausted Memory Monocytes and Underlying Mechanisms.
Pradhan K, Yi Z, Geng S, Li L. Pradhan K, et al. Front Immunol. 2021 Oct 28;12:778830. doi: 10.3389/fimmu.2021.778830. eCollection 2021. Front Immunol. 2021. PMID: 34777396 Free PMC article.
In this report, we examined the generation of exhausted primary murine monocytes through prolonged and repetitive challenges with high dose bacterial endotoxin lipopolysaccharide (LPS). We demonstrated that repetitive LPS challenges skew monocytes into the classically exha …
In this report, we examined the generation of exhausted primary murine monocytes through prolonged and repetitive challenges with high dose …
TICAM-1 and TICAM-2: toll-like receptor adapters that participate in induction of type 1 interferons.
Seya T, Oshiumi H, Sasai M, Akazawa T, Matsumoto M. Seya T, et al. Int J Biochem Cell Biol. 2005 Mar;37(3):524-9. doi: 10.1016/j.biocel.2004.07.018. Int J Biochem Cell Biol. 2005. PMID: 15618008 Review.
Toll-like receptor (TLR) 3 and 4 mediate the expression of many genes, including NF-kappaB- and interferon-regulatory factor (IRF)-3/interferon (IFN)-inducible genes, in macrophages and dendritic cells (DCs) in response to their ligand stimuli, polyI:C and lipopolysaccharide …
Toll-like receptor (TLR) 3 and 4 mediate the expression of many genes, including NF-kappaB- and interferon-regulatory factor (IRF)-3/interfe …
Hepatic effects of aminoglutethimide: a model aromatic amine.
Ng W, Metushi IG, Uetrecht J. Ng W, et al. J Immunotoxicol. 2015 Jan-Mar;12(1):24-32. doi: 10.3109/1547691X.2013.867912. Epub 2013 Dec 19. J Immunotoxicol. 2015. PMID: 24350727
Pathway-specific PCR arrays found few AMG-induced gene changes associated with an immune response and, of these changes, the majority were involved with innate immunity such as Tlr2, Ticam2, CD14, and C3. AMG treatment also led to significant changes in the apoptosi …
Pathway-specific PCR arrays found few AMG-induced gene changes associated with an immune response and, of these changes, the majority were i …
Varying importance of soluble and membrane CD14 in endothelial detection of lipopolysaccharide.
Lloyd-Jones KL, Kelly MM, Kubes P. Lloyd-Jones KL, et al. J Immunol. 2008 Jul 15;181(2):1446-53. doi: 10.4049/jimmunol.181.2.1446. J Immunol. 2008. PMID: 18606699
The endothelial response to LPS is critical in the recruitment of leukocytes, thereby allowing the host to survive Gram-negative infection. Herein, we investigated the roles of soluble CD14 (sCD14) and membrane CD14 (mCD14) in the endothelial response to low level L …
The endothelial response to LPS is critical in the recruitment of leukocytes, thereby allowing the host to survive Gram-negative infection. …
The NF-κB signalling pathway in colorectal cancer: associations between dysregulated gene and miRNA expression.
Slattery ML, Mullany LE, Sakoda L, Samowitz WS, Wolff RK, Stevens JR, Herrick JS. Slattery ML, et al. J Cancer Res Clin Oncol. 2018 Feb;144(2):269-283. doi: 10.1007/s00432-017-2548-6. Epub 2017 Nov 29. J Cancer Res Clin Oncol. 2018. PMID: 29188362 Free PMC article.
RESULTS: Of the 92 genes evaluated, 22 were significantly downregulated and nine genes were significantly upregulated in all tumours. Two additional genes (CD14 and CSNK2A1) were dysregulated in MSS tumours and two genes (CARD11 and VCAM1) were downregulated and six genes …
RESULTS: Of the 92 genes evaluated, 22 were significantly downregulated and nine genes were significantly upregulated in all tumours. Two ad …
Neisseria meningitidis capsular polysaccharides induce inflammatory responses via TLR2 and TLR4-MD-2.
Zughaier SM. Zughaier SM. J Leukoc Biol. 2011 Mar;89(3):469-80. doi: 10.1189/jlb.0610369. Epub 2010 Dec 29. J Leukoc Biol. 2011. PMID: 21191086 Free PMC article.
CPS induced IL-8 release from HEK cells stably transfected with TLR2/6, TLR2, TLR2/CD14, and TLR4/MD-2/CD14 but not HEK cells alone. mAb to TLR2 but not an isotype control antibody blocked CPS-induced IL-8 release from HEK-TLR2/6-transfected cells. ...CD14 an …
CPS induced IL-8 release from HEK cells stably transfected with TLR2/6, TLR2, TLR2/CD14, and TLR4/MD-2/CD14 but not HEK cells …
Integrated approaches for the recognition of small molecule inhibitors for Toll-like receptor 4.
Verma S, Reddy P, Sowdhamini R. Verma S, et al. Comput Struct Biotechnol J. 2023 Jul 22;21:3680-3689. doi: 10.1016/j.csbj.2023.07.026. eCollection 2023. Comput Struct Biotechnol J. 2023. PMID: 37576745 Free PMC article.
Toll-like receptors (TLRs) are pattern recognition receptors present on the surface of cells playing a crucial role in innate immunity. One of the TLRs, TLR4, recognizes LPS (Lipopolysaccharide) as its ligand leading to the release of anti-inflammatory mediat …
Toll-like receptors (TLRs) are pattern recognition receptors present on the surface of cells playing a crucial role in innate …
Suppression of mouse miRNA-222-3p in response to Echinococcus multilocularis infection.
Zheng Y. Zheng Y. Int Immunopharmacol. 2018 Nov;64:252-255. doi: 10.1016/j.intimp.2018.09.004. Epub 2018 Sep 11. Int Immunopharmacol. 2018. PMID: 30212751

Although all the pro- and anti-inflammatory cytokine genes tested kept constant in expression, four key genes involved in the LPS/TLR4 signaling pathway were significantly down- or up-regulated in transfected cells (p < 0.05), including CD14, TLR4, TICAM2 and AP-

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Although all the pro- and anti-inflammatory cytokine genes tested kept constant in expression, four key genes involved in the LPS/TLR4 signa …
37 results